Use of amphpramone, femproporex, mazindol and sibutramin in the treatment of patients with overweight or obesity: pharmacological and clinical analysis
Keywords:Overweight, Obesity, Amfepramone, Fenproporex, Mazindol, Sibutramine.
AbstractObesity is a disorder of energy metabolism in which there is excessive triglyceride accumulation in adipose tissue. Today, there is increasing media appeal towards an ever-growing search for thinness. Thus, there is an increase in the use of anorexigens, also known as appetite suppressants, in an abusive and irrational manner, leading to the development of chronic diseases, such as type 2 diabetes mellitus, hypertension and cardiovascular diseases, besides causing severe adverse reactions, such as increased blood pressure, dry mouth, increased heart rate, insomnia, constipation, nervousness, among others. The main appetite suppressant drugs are: amfepramone, fenproporex, mazindol and sibutramine. The main objective of this article is to identify the main impacts on the cardiovascular system of the use of appetite suppressants. The present work is a theoretical research though bibliographic survey and search for on-topic articles. Searches will also be carried out in electronic databases. Conclusion: These drugs should be used with caution, as they present contraindications and serious side effects, and may even cause dependence.
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