Differential diagnosis of leptospirosis: summary of main clinical evidences


  • Gabriel Antonio da Costa Nunes
  • Laís Sette Rostirola
  • Mateus Henrique Reinato
  • Eduardo Bazanelli Junqueira Ferraz




Clinical Medicine, Diagnosis, Leptospirosis.


Introduction: Leptospirosis is a serious clinical condition that manifests with pulmonary hemorrhage and acute kidney injury, leading to multiple organ failure in about 5 to 15% of cases. In situations where diagnosis is late and treatment is delayed, the mortality rate can reach about 50%. Identifying patients at risk of developing leptospirosis in its severe form is not easy for the clinician. Although laboratory and radiological support facilitates diagnosis, this is not a reality in low- and middleincome countries. Objective: To perform a literature review to highlight the main guidelines for the differential diagnosis of leptospirosis. Method: This is an exploratory study conducted in the PUBMED database, using the search strategy leptospirosis [title] AND diagnosis [title], including only clinical trials studies. Results: We included 10 articles in this review. Evidence Synthesis: Despite a number of effective laboratory methods for the diagnosis of leptospirosis, the use of scores based on clinical characteristics seems to be a promising way to make an early and assertive diagnosis, especially in places where health conditions are poor.

How to Cite

Nunes, G. A. da C., Rostirola, L. S., Reinato, M. H., & Ferraz, E. B. J. (2019). Differential diagnosis of leptospirosis: summary of main clinical evidences. International Journal of Health Management Review, 5(2). https://doi.org/10.37497/ijhmreview.v5i2.173